Table 3.
Association between each of the 18 SNPs and genetic risk score and risk of serous ovarian cancer, stratified by ET use after age 50
| Main effect | No ET use (N = 1,131 cases/3,500 controls) | ET use (N = 283 cases/551 controls) | p Value for interaction | ||||
|---|---|---|---|---|---|---|---|
| OR1,2 | 95% CI | OR1 | 95% CI | OR1 | 95% CI | ||
| SNP | |||||||
| rs58722170 | 1.25 | 1.11–1.40 | 1.21 | 1.06–1.38 | 1.41 | 1.07–1.85 | 0.31 |
| rs10069690 | 1.14 | 1.03–1.26 | 1.08 | 0.96–1.21 | 1.51 | 1.19–1.91 | 0.013 |
| chr10:21878831:D | 1.14 | 1.03–1.26 | 1.15 | 1.03–1.29 | 1.09 | 0.86–1.38 | 0.68 |
| rs17329882 | 1.14 | 1.02–1.28 | 1.17 | 1.03–1.32 | 1.05 | 0.81–1.37 | 0.47 |
| rs1879586 | 1.15 | 1.01–1.30 | 1.17 | 1.02–1.34 | 1.04 | 0.78–1.37 | 0.44 |
| rs56318008 | 1.16 | 1.03–1.31 | 1.22 | 1.06–1.39 | 0.93 | 0.698–1.25 | 0.099 |
| rs4808075 | 1.18 | 1.07–1.31 | 1.20 | 1.07–1.34 | 1.13 | 0.90–1.42 | 0.64 |
| chr9:136138765:D | 1.08 | 0.93–1.26 | 1.14 | 0.96–1.34 | 0.89 | 0.63–1.26 | 0.21 |
| rs7207826 | 1.17 | 1.06–1.29 | 1.19 | 1.06–1.33 | 1.06 | 0.84–1.35 | 0.39 |
| rs76837345 | 1.19 | 0.98–1.44 | 1.27 | 1.03–1.57 | 0.88 | 0.55–1.39 | 0.14 |
| rs62274042 | 1.65 | 1.36–2.01 | 1.59 | 1.28–1.97 | 1.98 | 1.24–3.14 | 0.40 |
| rs635634 | 1.14 | 1.01–1.29 | 1.16 | 1.01–1.33 | 1.06 | 0.80–1.40 | 0.56 |
| rs3744763 | 0.89 | 0.81–0.97 | 0.89 | 0.80–0.98 | 0.88 | 0.72–1.09 | 0.97 |
| chr17:29181220:I | 0.89 | 0.80–0.99 | 0.88 | 0.78–0.99 | 0.93 | 0.72–1.19 | 0.71 |
| rs6755777 | 0.98 | 0.89–1.09 | 0.98 | 0.88–1.10 | 0.99 | 0.80–1.24 | 0.94 |
| rs117224476 | 0.73 | 0.64–0.84 | 0.76 | 0.65–0.88 | 0.62 | 0.45–0.85 | 0.26 |
| rs1400482 | 0.80 | 0.69–0.92 | 0.81 | 0.69–0.95 | 0.77 | 0.54–1.09 | 0.79 |
| rs116133110 | 0.86 | 0.78–0.95 | 0.87 | 0.78–0.97 | 0.83 | 0.66–1.04 | 0.69 |
| Risk score quartile | |||||||
| 2nd vs. 1st quartile | 1.15 | 0.94–1.41 | 1.18 | 0.95–1.48 | 0.98 | 0.61–1.59 | 0.52 |
| 3rd vs. 1st quartile | 1.56 | 1.29–1.90 | 1.53 | 1.24–1.90 | 1.77 | 1.12–2.81 | |
| 4th vs. 1st quartile | 2.26 | 1.87–2.72 | 2.31 | 1.88–2.85 | 2.00 | 1.30–3.08 | |
1
Adjusted for OC use (never (including <1), 1 to <2, 2 to <5, 5 to <10, 10+ years), parity (0, 1, 2+ births), hysterectomy, endometriosis, tubal ligation and education (less than high school, high school graduate, some college, college graduate or more); conditioned on age (50–54, 55–59, 60–64, 65–69, 70–74, 75+), genetic ancestry (European, African, Asian, other) and analytic set.
2
All SNP main effects show genome-wide significance (p ≤ 5.0 × 10−8) in the full OCAC dataset.
Abbreviations: OR, odds ratio; CI, confidence interval.
p Values significant at a ≤0.05 level are indicated in bold.