Table 4.
Association between each of the 18 SNPs and genetic risk score and risk of endometrioid ovarian cancer, stratified by ET use after age 50
| Main effect | No ET use (N = 286 cases/3,500 controls) | ET use (N = 51 cases/551 controls) | p Value for interaction | ||||
|---|---|---|---|---|---|---|---|
| OR1,2 | 95% CI | OR1 | 95% CI | OR1 | 95% CI | ||
| SNP | |||||||
| rs58722170 | 0.95 | 0.76–1.20 | 0.97 | 0.75–1.25 | 0.87 | 0.50–1.52 | 0.73 |
| rs10069690 | 0.98 | 0.81–1.20 | 0.93 | 0.75–1.16 | 1.32 | 0.82–2.15 | 0.20 |
| chr10:21878831:D | 1.08 | 0.89–1.30 | 1.03 | 0.84–1.27 | 1.30 | 0.81–2.08 | 0.39 |
| rs17329882 | 1.07 | 0.87–1.32 | 1.11 | 0.88–1.39 | 0.90 | 0.52–1.56 | 0.48 |
| rs1879586 | 0.97 | 0.76–1.24 | 0.99 | 0.77–1.29 | 0.83 | 0.46–1.52 | 0.59 |
| rs56318008 | 1.40 | 1.13–1.74 | 1.53 | 1.21–1.92 | 0.82 | 0.46–1.45 | 0.037 |
| rs4808075 | 1.01 | 0.83–1.22 | 1.02 | 0.83–1.25 | 0.97 | 0.60–1.56 | 0.84 |
| chr9:136138765:D | 0.99 | 0.74–1.31 | 1.03 | 0.76–1.41 | 0.74 | 0.35–1.55 | 0.41 |
| rs7207826 | 1.21 | 1.01–1.45 | 1.32 | 1.09–1.61 | 0.71 | 0.43–1.18 | 0.021 |
| rs76837345 | 1.25 | 0.89–1.75 | 1.14 | 0.78–1.68 | 1.69 | 0.83–3.46 | 0.35 |
| rs62274042 | 1.12 | 0.75–1.68 | 1.10 | 0.70–1.70 | 1.34 | 0.47–3.75 | 0.73 |
| rs635634 | 1.04 | 0.83–1.31 | 1.10 | 0.86–1.41 | 0.76 | 0.41–1.42 | 0.28 |
| rs3744763 | 1.06 | 0.89–1.26 | 1.07 | 0.89–1.28 | 1.00 | 0.65–1.54 | 0.79 |
| chr17:29181220:I | 0.81 | 0.66–0.99 | 0.81 | 0.65–1.01 | 0.80 | 0.49–1.32 | 0.97 |
| rs6755777 | 1.01 | 0.84–1.21 | 0.98 | 0.81–1.20 | 1.14 | 0.73–1.78 | 0.56 |
| rs117224476 | 0.79 | 0.62–1.02 | 0.85 | 0.65–1.11 | 0.54 | 0.28–1.06 | 0.21 |
| rs1400482 | 0.98 | 0.76–1.26 | 0.92 | 0.70–1.21 | 1.36 | 0.73–2.52 | 0.26 |
| rs116133110 | 1.04 | 0.87–1.24 | 1.08 | 0.89–1.31 | 0.85 | 0.55–1.31 | 0.32 |
| Risk score quartile | |||||||
| 2nd vs. 1st quartile | 1.49 | 1.04–2.14 | 1.40 | 0.94–2.09 | 1.98 | 0.79–4.94 | 0.25 |
| 3rd vs. 1st quartile | 1.69 | 1.18–2.40 | 1.65 | 1.12–2.42 | 2.04 | 0.80–5.17 | |
| 4th vs. 1st quartile | 1.73 | 1.22–2.46 | 1.85 | 1.27–2.70 | 1.10 | 0.42–2.91 | |
1
Adjusted for OC use (never (including <1), 1 to <2, 2 to <5, 5 to <10, 10+ years), parity (0, 1, 2+ births), hysterectomy, endometriosis, tubal ligation and education (less than high school, high school graduate, some college, college graduate or more); conditioned on age (50–54, 55–59, 60–64, 65–69, 70–74, 75+), genetic ancestry (European, African, Asian, other) and analytic set.
2
All SNP main effects show genome-wide significance (p ≤ 5.0 × 10−8) in the full OCAC dataset.
Abbreviations: OR, odds ratio; CI, confidence interval.
p Values significant at a ≤0.05 level are indicated in bold.