Table 2.
Autoantibodies in SSc patients with and without calcinosis
Sample size n (%) | Without calcinosis n (%) | With calcinosis n (%) | p Value | |
---|---|---|---|---|
Positive ANA | 4689 (89.9) | 3316/3494 (94.9) | 1123/1195 (94) | 0.2164 |
Positive Scl-70 | 4578 (87.7) | 698/3409 (20.5) | 166/1169 (14.2) | < 0.0001 |
Positive ACA | 3370 (64.6) | 717/2651 (27.1) | 277/719 (38.5) | < 0.0001 |
Positive anti-PM/Scl | 1825 (35) | 87/1365 (6.4) | 49/460 (10.7) | 0.0025 |
Positive RNA-polymerase-III | 2414 (46.3) | 481/1772 (27.1) | 143/642 (22.3) | 0.0157 |
Positive U1-RNP | 4286 (82.1) | 238/3174 (7.5) | 47/1112 (4.2) | 0.0002 |
Positive Lupus anticoagulant | 1637 (31.4) | 44/1118 (3.9) | 28/519 (5.4) | 0.1803 |
Positive anti-beta-2-glycoprotein | 588 (11.3) | 105/401 (26.2) | 46/187 (24.6) | 0.6819 |
Positive anticardiolipin | 949 (18.2) | 200/653 (30.6) | 125/296 (42.2) | 0.0005 |
Abbreviations: ANA = antinuclear, ACA = anticentromere, RNP = ribonucleoprotein.