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. Author manuscript; available in PMC: 2018 May 30.
Published in final edited form as: J Labelled Comp Radiopharm. 2017 Apr 16;60(6):274–285. doi: 10.1002/jlcr.3498

Scheme 1.

Scheme 1

Synthesis of non-deuterated 2A

Reagents: (a) TBDMSCl, imidazole, 61%; (b) (i) 1-bromobutane (3A), Mg0, THF (ii) CuCl2, LiCl, NMP, 93%; (c) TBAF, 87.4%; (d) Bobbitt’s salt, SiO2, 90.8%; (e) SnCl2, ethyl diazoacetate, 89.6%; (f) NaBH4, 77.6%; (g) LiOH, 83.6%; (h) (i) NHS, EDC, DMAP (ii) Pd/C, H2, 67%; (i) TBAF, 80.5% (j) LiOH, 84%; (k) 13-methylpentadecanoic acid, EDC, DMAP, 63.4%; (l) TBAF, 76.1% (m) KOSi(CH)3, 65%.