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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Mol Cancer Res. 2017 Mar 30;15(7):831–841. doi: 10.1158/1541-7786.MCR-16-0218

Figure 4. Analysis of changes in mtDNA and nDNA in AOM-induced tumors using QPCR.

Figure 4

(A) AOM-induced changes in mtDNA abundance in tumors from WT and Apex1+/- mice. (B) Mitochondrial DNA lesions in AOM-induced tumors from WT and Apex1+/- mice. (C) Nuclear DNA lesions in AOM-induced tumors from WT and Apex1+/- mice. Open histograms represent normal tissue and closed histograms represent tumor tissue. Results are expressed as mean ± SEM values for 3 QPCRs performed in triplicate. N=6 for saline treated mice; N=8 mice for AOM treated mice. Asterisks (*) denote statistical significance (One-way ANOVA, * P<0.05; ** P<0.01; *** P<0.001).