Table 2. List of EGFR gene mutations detected by three different methods.
| EGFR | Pyrosequencing | PNA-clamping | Cobas assay |
|---|---|---|---|
| Exon 18 | G719A | G719A | G719A |
| G719S | G719S | G719C | |
| G719C | G719C | G719S | |
| Exon 19 | E746_A750del | E746_A750del | E746_T751 > A |
| E746_A751delinsI | E746_T751 > I | L747_T751del | |
| E746_S752del | E746_T751del | L747_E749del | |
| E746_T751delinsA | E746_T751 > A | E746_T751 > I | |
| E746_S752 > A | E746_S752 > A | E746_T751del | |
| E746_S752delinsV | E746_S752 > V | E746_S752 > A | |
| E746_A750del | E746_A750del | E746_S752 > D | |
| E746_S752delinsD | E746_S752 > D | L747_A750 > P | |
| L747_A750 > P | L747_A750 > P | L747_T751 > Q | |
| L747_T751delinsD | L747_T751 > Q | L747_P753 > Q | |
| L747_E749del | L747_E749del | L747_T751 > S | |
| L747_T751del | L747_T751del | K745_E749del | |
| L747_S752del | L747_S752del | E746_A750 > IP | |
| L747_E749del;A750P | L747_ A750 > P | E746_T751 > V | |
| L747_P753delinsQ | L747_P753 > Q | E746_T751 > IP | |
| L747_T751delinsS | L747_T751 > S | E746_S752 > I | |
| L747_P753delinsS | L747_P753 > S | L747_S752 > Q | |
| L747_T751del | L747_T751del | L747S | |
| L747_T751delinsP | L747_T751 > P | ||
| E746_S752 > I | |||
| E746_P753 > VS | |||
| L747_T751del | |||
| L747_S752 > Q | |||
| Exon 20 | T790M | T790M | T790M |
| S768I | S768I | S768I | |
| A767_V769dupASV | H773_V774insH | Insertions | |
| H773dupH | P772_H773insTTP | ||
| D770_N771insG | P772_H773insGNP | ||
| H773L | |||
| H773_V774insPH | |||
| V774_C775insHV | |||
| Exon 21 | L858R | L858R | L858R |
| L861Q | L861Q |
EGFR=epidermal growth factor receptor; PNA-clamping=peptide nucleic acid-mediated polymerase chain reaction; del=deletion; delins=deletioninsertion; dup; duplication; ins=insertion.