Table 6. Summary of previous studies for EGFR gene mutation in triple-negative breast cancer.
| Author (year) | Specimen | Population | Method | Result | |
|---|---|---|---|---|---|
| Reis-Filho et al. (2006) [16] | 47 | Metaplastic carcinomas | British | Direct sequencing | No mutations |
| Toyama et al. (2008) [13] | 58 | TNBCs | Japanese | Real-time PCR | No mutations |
| Jacot et al. (2011) [15] | 229 | TNBCs | French | Direct sequencing | No mutations |
| Lv et al. (2011) [18] | 139 | Breast carcinomas | Chinese | Real-time PCR | 1.4% (10% in TNBCs), 19del and L858R |
| Teng et al. (2011) [19] | 70 | TNBCs | Chinese | Direct sequencing | 11.4%, 19del and L858R |
| Martin et al. (2012) [11] | 38 | TNBC with basal-like features | Switzerland | Direct sequencing | No mutations |
| Grob et al. (2012) [10] | 65 | TNBCs | German | Direct sequencing | No mutations |
| Santarpia et al. (2012) [17] | 116 | TNBCs | American | Sequenom technology | 3.4%, Mutation types, not specified |
| Direct sequencing | |||||
| Kim et al. (2013) [20] | 105 | TNBCs | Korean | PNA-clamping | 1.0%, 19del |
| Secq et al. (2014) [12] | 47 | TNBCs | French | Direct sequencing | No mutations |
| Tilch et al. (2014) [14] | 50 | TNBCs | Australian | Direct sequencing | No mutations |
| 57 | Basal-like breast carcinomas | ||||
| Nakajima et al. (2014) [9] | 55 | TNBCs | Japanese | SmartAmp2 method | No mutations |
| Park et al. (2014) [21] | 151 | TNBCs | Korean | Direct sequencing | 2.6%, G719A, V786M, L858R |
REGFR=epidermal growth factor receptor; TNBC=triple-negative breast cancer; PCR=polymerase chain reaction; del=deletion; PNA-clamping=peptide nucleic acid-mediated polymerase chain reaction.