Figure 1. MORT gene silencing is early event in cancer. (A, B) DNA methylation of the MORT promoter in two independent cohorts of breast ductal carcinoma in situ (DCIS) patients. (C) DNA methylation of the MORT promoter in 44 pairs of primary breast tumors and lymph node metastasis. (D) DNA methylation of the MORT promoter as determined by reduced representation bisulfite sequencing in a DCIS cohort. (E, F) DNA methylation of the MORT promoter in two independent cohorts of colon adenomas and carcinomas. All data except (D) were obtained using the Illumina Human Methylation 450 platform. Where more than two groups are presented the p-value is for in situ lesions versus normal samples.

IBC=invasive breast cancer.