Table 2.
Multivariate and Univariate Analysis for YTMA 49 and YTMA 201
| Multivariate | Univariate | Multivariate | Univariate | |||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
|
Characteristics Age at Diagnosis |
YTMA 49 | YTMA 201 | ||||||
|
| ||||||||
| <50 | 1 | 0.100 | 1 | 0.5013 | 1 | 0.407 | 1 | 0.609 |
| ≥50 | 1.373 (0.940–2.004) | 1.129(0.792–1.610) | 1.458(0.592–3.552) | 0.820(0.384–1.752) | ||||
|
| ||||||||
| Tumor Size | ||||||||
|
| ||||||||
| ≤2 cm | 1 | <0.0001 | 1 | <0.0001 | 1 | 0.030 | 1 | 0.005 |
| 2–5 cm | 3.680 (2.265–5.977) | 4.198(2.610–6.753) | 2.791 (1.103–7.061) | 3.022(1.401–6.522) | ||||
|
| ||||||||
| Nuclear Grade | ||||||||
|
| ||||||||
| Grade 1 | 1 | 0.267 | 1 | 0.0089 | ------ | ------ | ||
| Grade 2 | 1.213(0.863–1.705) | 0.642(0.461–0.895) | ||||||
|
| ||||||||
| Nodal Status | ||||||||
|
| ||||||||
| Negative | 1 | 0.0003 | 1 | <0.0001 | 1 | 0.006 | 1 | 0.002 |
| Positive | 1.967 (1.361–2.843) | 2.490 (1.764–35.16) | 3.456 (1.420–8.414) | 3.815(1.646–8.840) | ||||
|
| ||||||||
| ER Status | ||||||||
|
| ||||||||
| Negative | 1 | 0.075 | 1 | <0.0001 | 1 | 0.532 | 1 | 0.061 |
| Positive | 0.719 (0.501–1.033) | 0.536 (0.393–0.732) | 0.749 (0.303–1.852) | 0.492 (0.231–1.003) | ||||
|
| ||||||||
| PR Status | ||||||||
|
| ||||||||
| Negative | 1 | 0.220 | 1 | 0.0004 | 1 | 0.370 | 1 | 0.147 |
| Positive | 0.813 (0.584–1.132) | 0.565 (0.412–0.773) | 0.388 (0.049–3.083) | 0.228 (0.031–1.680) | ||||
|
| ||||||||
| HER2 Status | ||||||||
|
| ||||||||
| Negative | 1 | 0.104 | 1 | 0.1882 | 1 | 0.363 | 1 | 0.263 |
| Positive | 1.406 (0.932–2.121) | 1.297 (0.881–1.910) | 1.597 (0.582–4.379) | 1.737 (0.660–4.573) | ||||
|
| ||||||||
| NCS-1 Expression (Q1–3 vs. Q4) | ||||||||
|
| ||||||||
| Q1–3 | 1 | 0.020 | 1 | <0.0001 | 1 | 0.004 | 1 | 0.004 |
| Q4 | 1.532 (1.070–2.193) | 2.036 (1.472–2.815) | 3.677 (1.509–8.956) | 3.008 (1.400–6.327) | ||||
HR: Hazard Ratio, CI: Confidence Interval, ER: Estrogen Receptor, PR: Progesterone Receptor, HER2: Human Epidermal Growth Factor Receptor 2, NCS-1: Neuronal Calcium Sensor-1