Table 6.
| Independent variables | Physical HRQOL | Mental HRQOL | ||
|---|---|---|---|---|
| Model 1a | Model 1b | Model 2a | Model 2b | |
| Beta (95% CI) | Beta (95% CI) | Beta (95% CI) | Beta (95% CI) | |
| Sensation abnormality | −1.44*** (−1.87, −1.01) | −1.09*** (−1.48, −0.69) | −1.04*** (−1.54, −0.54) | −0.91*** (−1.41, −0.41) |
| Pain | −5.24*** (−5.72, −4.76) | −4.01*** (−4.46, −3.55) | −2.21*** (−2.68, −1.74) | −1.76*** (−2.23, −1.28) |
| Fatigue | −3.74*** (−4.24, −3.25) | −3.31*** (−3.78, −2.85) | −1.33*** (−1.83, −0.83) | −1.17*** (−1.66, −0.67) |
| Cognition disturbance | −3.38*** (−4.01, −2.75) | −2.32*** (−2.90, −1.75) | −3.70*** (−4.35, −3.06) | −3.31*** (−3.95, −2.66) |
| Depression | −2.72*** (−3.29, −2.16) | −2.54*** (−3.07, −2.00) | −5.27*** (−5.88, −4.65) | −5.20*** (−5.81, −4.59) |
| Anxiety | −0.94** (−1.48, −0.41) | −0.91*** (−1.42, −0.41) | −1.87*** (−2.42, −1.33) | −1.86*** (−2.40, −1.32) |
| Cancer experience (Ref: Non-cancer individuals) | ||||
| Cancer survivors | −0.59* (−1.81, −0.09) | −0.65 (−1.43, 0.13) | −0.35 (−1.29, 0.59) | −0.23 (−1.18, 0.72) |
| Number of chronic conditions (Ref: None) | ||||
| 1 | N/A | −4.81*** (−5.47, −4.14) | N/A | −1.79*** (−2.46, −1.11) |
| 2 and above | N/A | −9.16*** (−10.17, −8.16) | N/A | −3.34*** (−4.36, −2.32) |
| Age at survey (Ref: 18–44.9 years old) | ||||
| 45–64.9 years old | −1.55*** (−2.04, −1.06) | −0.87*** (−1.34, −0.41) | −0.84** (−1.37, −0.31) | −0.59* (−1.13, −0.06) |
| ≥65 years old | −2.60*** (−3.34, −1.87) | −1.01** (−1.74, −0.28) | −0.24 (−0.94, 0.47) | 0.34 (−0.40, 1.08) |
| Gender (Ref: Male) | ||||
| Female | −0.46* (−0.89, −0.03) | −0.37 (−0.77, 0.03) | 0.43* (0.02, 0.85) | 0.46* (0.05, 0.88) |
| Race/ethnicity (Ref: White) | ||||
| Hispanic | −0.59 (−1.24, 0.06) | −0.73* (−1.35, −0.10) | −1.02** (−1.66, −0.37) | −1.07** (−1.71, −0.43) |
| Non-Hispanic Black | −1.12** (−1.81, −0.43) | −0.95** (−1.60, −0.29) | −1.44*** (−2.08, −0.79) | −1.37*** (−2.02, −0.73) |
| Non-Hispanic Asian | 0.06 (−0.80, 0.92) | −0.03 (−0.85, 0.79) | −1.56** (−2.46, −0.67) | −1.60** (−2.50, −0.70) |
| Non-Hispanic other races | −2.45* (−4.52, −0.38) | −1.44 (−3.67, 0.80) | −3.00* (−5.55, −0.45) | −2.64* (−5.03, −0.24) |
| Marital status (Ref: Married) | ||||
| Separated | −0.91 (−2.30, 0.49) | −1.10 (−2.40, 0.20) | −3.66*** (−4.79, −2.52) | −3.73*** (−4.85, −2.61) |
| Divorced | −0.63 (−1.36, 0.11) | −0.40 (−1.12, 0.33) | −2.19*** (−2.87, −1.51) | −2.11*** (−2.79, −1.42) |
| Single/never married | −0.07 (−0.60, 0.45) | −0.04 (−0.54, 0.45) | −1.53*** (−2.09, −0.98) | −1.52*** (−2.07, −0.97) |
| Widowed | −1.34** (−2.20, −0.49) | −0.61 (−1.42, 0.21) | −1.39** (−2.24, −0.54) | −1.12** (−1.96, −0.28) |
| Education (Ref: Graduate degree) | ||||
| Below high school | −4.58*** (−5.56, −3.60) | −3.91*** (−4.86, −2.96) | −6.00*** (−6.97, −5.03) | −5.76*** (−6.73, −4.79) |
| High school/GED | −2.76*** (−3.52, −2.00) | −2.32*** (−3.04, −1.59) | −4.16*** (−5.03, −3.28) | −3.99*** (−4.97, −3.12) |
| Some college | −2.35*** (−3.09, −1.61) | −1.91*** (−2.60, −1.22) | −2.80*** (−3.63, −1.98) | −2.64*** (−3.46, −1.83) |
| Bachelor degree | −0.35 (−1.13, 0.42) | −0.16 (−0.89, 0.57) | −1.08* (−1.93, −0.24) | −1.01* (−1.85, −0.17) |
| Variance explained, % | 43.3% | 49.3% | 37.0% | 37.8% |
#
Numbers in the Table were weighted to represent the entire U.S. non-institutionalized adults.
†
Based on multivariable analyses adjusting for independent variables: Models 1a and 2a included the following independent variables: 6 symptom phenotypes, cancer experience, and age, sex, race/ethnicity, marital status, and education; Models 1b and 2b included the independent variables listed in Models 1a and 2a plus chronic conditions.
*
p<0.05
**
p<0.01,
***
p<0.001.