Table 2.
In-air light fluence and in-air light fluence rate conditions used in each PDT treatment group.
| Index | Fluence (J/cm2) | ϕair (mW/cm2) | PDT dose (μM J/cm2) | Photofrin (μM) | Photofrin variation† (μM) | [1O2]rx (mM) | [1O2]rx variation† (mM) | Variation count† |
|---|---|---|---|---|---|---|---|---|
| 1 | 50 | 50 | 126.5 | 3.5 | - | 0.35 | - | 0 / 4 |
| 2 | 75 | 235.5 | 6.0 | - | 0.40 | - | 0 / 5 | |
| 3 | 150 | 199.9 | 4.9 | - | 0.24 | - | 0 / 4 | |
|
| ||||||||
| 4 | 135 | 50 | 229.7 | 3.0 | 2.52 / 4.33* | 0.66 | 0.45/0.91# | 1 / 4 |
| 5 | 75 | 774.2 | 7.8 | 3.08 / 12.1* | 0.93 | 0.27/1.25# | 10 / 12 | |
| 6 | 150 | 322.3 | 3.5 | - | 0.53 | - | 0 / 4 | |
|
| ||||||||
| 7 | 200 | 50 | 204.8 | 2.2 | - | 0.63 | - | 0 / 5 |
| 8 | 150 | 417.8 | 3.8 | - | 0.76 | - | 0 / 5 | |
|
| ||||||||
| 9 | 250 | 50 | 362.1 | 3.4 | 3.17 / 3.66* | 1.03 | 0.97 / 1.09# | 3 / 4 |
| 10 | 75 | 1380.1 | 5.8 | 1.88 / 12.6* | 0.74 | 0.65 / 1.32# | 8 / 10 | |
| 11 | 150 | 393.0 | 3.1 | 2.45 / 5.32* | 0.81 | 0.69 / 1.04# | 2 / 9 | |
|
| ||||||||
| Control | 0 | 0 | 0 | - | 0 | - | 0 / 8 | |
*
Photofrin concentration in tumors with complete and partial response is significantly different, p<0.05.
#
[1O2]rx concentration tumors with complete and partial response is significantly different, p<0.05
†
Variation is shown for (tumors with complete response) / (total number of tumors) at 14 days.