Table 2.
Analytes | Study 1
|
Study 2
|
||||
---|---|---|---|---|---|---|
UGT2B10 Null (n = 60) |
UGT2B10 Non-null (n = 735) |
P value | UGT2B10 Null (n = 37) |
UGT2B10 Non-null (n = 614) |
P value | |
|
|
|||||
Total Nicotineb | 20 (21.1) | 18.5 (11.5) | 0.571 | 14.7 (12.6) | 15.2 (10.9) | 0.796 |
Nicotine-N-oxideb | 8.2 (4.9) | 7 (4.4) | 0.067 | 7.7 (5.4) | 5.6 (4.2) | 0.028 |
Cotinineb | 21.5 (9.7) | 13.1 (5.9) | < 0.001 | 20.6 (7.9) | 11.4 (5.3) | < 0.001 |
Cotinine glucuronideb | ND | 17.2 (8.4) | < 0.001 | ND | 16 (7.1) | < 0.001 |
Total 3-hydroxycotinineb | 52.2 (17.9) | 44.3 (16.2) | 0.002 | 58.3 (19.9) | 51.7 (16.3) | 0.057 |
C-oxidation (sum of total cotinine and total 3-hydroxycotinine)b | 73.4 (16.4) | 74.5 (13.7) | 0.601 | 77.7 (15.8) | 79.2 (13.6) | 0.582 |
TNEb (nmol/ml) | 56.6 (36.6) | 57.1 (39.8) | 0.929 | 57.4 (39.1) | 78.8 (53.9) | 0.003 |
TNEc (nmol/ml) | 45.1 (39.6) | 45.7 (44.8) | 0.895 | 47.3 (45.5) | 62.7 (56.8) | 0.012 |
Number of African Americans (%) | 45 (75%) | 248 (33.7%) | < 0.001 | 31 (83.8%) | 169 (27.5%) | < 0.001 |
UGT2B10 phenotype was characterized by cotinine glucuronidation, smokers with no quantifiable cotinine glucuronide are defined as null, values for each analyte are the percentage of TNE.
mean (SD), ND, not detected (nmol total cotinine/nmol cotinine <1.1, based on a coefficient of variation of 9.6%)
geometric mean (interquartile range)