Skip to main content
. Author manuscript; available in PMC: 2017 Aug 24.
Published in final edited form as: Chem Rev. 2017 Jan 6;117(16):10726–10759. doi: 10.1021/acs.chemrev.6b00582

Figure 10.

Figure 10

2D IR spectroscopy of β-amyloid (Aβ-40) revealed the existence of kinetically trapped water. (a) A pictorial representation of possible locations of water molecules inside Aβ40 fibrils. (b) Enlarged view of the region outlined in part a. The evolution of nodal slopes of specific residues, shown in part c, indicates the presence of water at certain interstrand locations. Adapted with permission from ref 109 (Copyright 2009 National Academy of Sciences.) and ref 103 (Copyright 2011 Elsevier.).