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. Author manuscript; available in PMC: 2017 Aug 24.
Published in final edited form as: Chem Rev. 2017 Jan 6;117(16):10726–10759. doi: 10.1021/acs.chemrev.6b00582

Figure 20.

Figure 20

Reorganization of a perturbed helix probed by 2D IR. Left: A schematic outline of the experimental principle. The helix is generated in a near-equilibrium, and the kinked conformation is generated by a tetrzine bridge in the backbone. The bridge can be photolyzed using UV light, following which 2D IR spectra reveal the backbone reorganization. Right: 2D IR diagonal widths as a function of the delay between the UV and the 2D IR pulse sequence, reflecting the backbone conformational rearrangement. Reproduced with permission from ref 22. Copyright 2013 National Academy of Sciences.