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. 2017 Jul 6;7:4787. doi: 10.1038/s41598-017-05305-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Summary diagram of the novel role of Znf179 in glioblastoma multiforme (GBM) cell cycle regulation and differentiation. Overexpression of Znf179 induces differentiation of primary GBM cells accompanied by elevated glial fibrillary acidic protein (GFAP) expression through upregulating several cell-cycle-related factors, i.e., p53, p21, and p27, and inducing cell-cycle arrest in the G₀/G₁ phase.