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. 2017 Jul 6;7:4828. doi: 10.1038/s41598-017-05143-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Subgroup analyses of LINE-1 methylation in gastric cancer patients according to clinicopathological data. LINE-1 methylation analyses based on (A) anatomical tumour localization (p = 0.41), (B) T- (p = 0.20), (C) N-, (p = 0.11) and (D) M-tumor staging (p = 0.17). (E) LINE-1 methylation differences in patients with low and high-grade tumors (p = 0.26). LINE-1 methylation differences in GC patients according to (F) Lauren’s classification of GC type (p = 0.39), (G) gender (p = 0.83) and (H) H. pylori status (p = 0.70). Statistical analyses were performed using Mann-Whitney for two and Kruskal-Wallis test with Dunn’s posttest for multiple comparison analyses.