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. 2017 Jul 6;7:4795. doi: 10.1038/s41598-017-05005-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of chrysin on ECG pattern, body and heart weight, and cardiotoxicity markers in rats subjected to chronic doxorubicin (DOX) intoxication. (A) ECG graph. (B) Heart rate (beat/min), (C) QRS duration (ms), (D) QTc interval (ms) (E) PR interval (ms). (F) Body weight (g), (G) Heart index (%), (H) CKMB activity (IU/L). And (I) LDH activity (IU/L). Data are represented as mean ± SD (n = 10). a or b: Statistically significant from the control or DOX group respectively at P < 0.05 using one-way analysis of variance ANOVA followed by Tukey-Kramer as a post-hoc test.