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. 2017 Jul 6;7:4792. doi: 10.1038/s41598-017-05029-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased spinal cord Src phosphorylation in cancer-induced bone pain is blocked by dasatinib. Ratios of spinal expression of phosphorylated Src (pSrc) to total Src (a,e) and phosphorylated NMDA receptor subunit 2B (pNR2B) to total NR2B (NR2B) (b,f). (a) Cancer-induced bone pain induces an increase of spinal pSrc/Src ratio expression at the time of euthanasia. Both high and low dose dasatinib significantly decreases the level of phosphorylation of Src compared to vehicle treated control. B: Representatives of Western Blot. (c) No significant changes of spinal pNR2B/NR2b ratio expression were observed between the five treatment groups at the time of euthanasia. (d) Representatives of Western Blot. (e,f): Timeline study of cancer-induced bone. No significant change in the expression of spinal pSrc/Src (e) or pNR2B/NR2B (f) is observed during development of cancer-induced bone pain in the female rat. One-way ANOVA followed by Bonferroni’s multiple comparison test. Data are displayed as mean ± SEM, n = 4–10. The blots displayed are cropped and the full-length blots are available in the Supplementary Information file.