Figure 14.

Apoptotic cell ratio. The renal cells of rats in the sham, DN, exenatide, and exenatide–PEG-b-(PELG₅₀-g-PLL₃) complex groups were collected after eight weeks, and results were expressed as mean ± SD. The quantitative analyses of Sham (A), DN (B), exenatide (C) and exenatide-PEG-b-(PELG₅₀-g-PLL₃) complex (D) in apoptotic cell ratio; (E) the qualitative analyses. A significant increase from the sham group, a significant decrease from the DN group, and a significant decrease from the DN (Exenatide-PEG-b-(PELG₅₀-g-PLL₃)) group is denoted by *P<0.01, **P<0.01, and ***P<0.01, respectively.

Abbreviations: DN, diabetic nephropathy; PEG-b-(PELG₅₀-g-PLL₃), poly(ethylene glycol)-b-brush poly(L-lysine) polymer.