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. 2017 Jun 29;12:4663–4678. doi: 10.2147/IJN.S136646

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© 2017 Tong. This work is published and licensed by Dove Medical Press Limited

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Body weight (A), FBG (B), FINS (C), serum lipid (D), HOMA-IR (E), and ISI (F). The body weight and serum of rats in the sham, DN, exenatide, and exenatide–PEG-b-(PELG₅₀-g-PLL₃) complex groups were collected after eight weeks, and results are expressed as mean ± SD. (A) A significant decrease from the sham, DN, and the DN (Exenatide-PEG-b-(PELG₅₀-g-PLL₃)) group is denoted by *P<0.01, **P<0.01, and ***P<0.01, respectively. (B) A significant increase from the sham group, a significant decrease from the DN group, and a significant decrease from the DN group is denoted by *P<0.01, **P<0.01, and ***P<0.01, respectively. (C) A significant increase from the sham group, a significant decrease from the DN group, and a significant decrease from the DN group is denoted by *P<0.01, **P<0.01, and ***P<0.01, respectively. (D) A significant increase from the sham group, a significant decrease from the DN group, and a significant decrease from the DN group is denoted by *P<0.01, **P<0.01, and ***P<0.01, respectively (TC, TG, and LDL); and a significant decrease from the sham group, a significant increase from the DN group, and a significant increase from the DN group is denoted by *P<0.01, **P<0.01, and ***P<0.01, respectively (HDL). (E) A significant increase from the sham group, a significant decrease from the DN group, and a significant decrease from the DN group is denoted by *P<0.01, **P<0.01, and ***P<0.01, respectively. (F) A significant increase from the sham group, a significant decrease from the DN group, and a significant decrease from the DN group is denoted by *P<0.01, **P<0.01, and ***P<0.01, respectively.

Abbreviations: FBG, fasting blood glucose; FINS, fasting plasma insulin; TC, total cholesterol; TG, triglyceride; LDL, low-density lipoprotein; HDL, high-density lipoprotein; HOMA-IR, homeostasis model insulin resistance index; ISI, insulin sensitivity index; DN, diabetic nephropathy; PEG-b-(PELG₅₀-g-PLL₃), poly(ethylene glycol)-b-brush poly(L-lysine) polymer.

Body weight (A), FBG (B), FINS (C), serum lipid (D), HOMA-IR (E), and ISI (F). The body weight and serum of rats in the sham, DN, exenatide, and exenatide–PEG-b-(PELG₅₀-g-PLL₃) complex groups were collected after eight weeks, and results are expressed as mean ± SD. (A) A significant decrease from the sham, DN, and the DN (Exenatide-PEG-b-(PELG₅₀-g-PLL₃)) group is denoted by *P<0.01, **P<0.01, and ***P<0.01, respectively. (B) A significant increase from the sham group, a significant decrease from the DN group, and a significant decrease from the DN group is denoted by *P<0.01, **P<0.01, and ***P<0.01, respectively. (C) A significant increase from the sham group, a significant decrease from the DN group, and a significant decrease from the DN group is denoted by *P<0.01, **P<0.01, and ***P<0.01, respectively. (D) A significant increase from the sham group, a significant decrease from the DN group, and a significant decrease from the DN group is denoted by *P<0.01, **P<0.01, and ***P<0.01, respectively (TC, TG, and LDL); and a significant decrease from the sham group, a significant increase from the DN group, and a significant increase from the DN group is denoted by *P<0.01, **P<0.01, and ***P<0.01, respectively (HDL). (E) A significant increase from the sham group, a significant decrease from the DN group, and a significant decrease from the DN group is denoted by *P<0.01, **P<0.01, and ***P<0.01, respectively. (F) A significant increase from the sham group, a significant decrease from the DN group, and a significant decrease from the DN group is denoted by *P<0.01, **P<0.01, and ***P<0.01, respectively.

Abbreviations: FBG, fasting blood glucose; FINS, fasting plasma insulin; TC, total cholesterol; TG, triglyceride; LDL, low-density lipoprotein; HDL, high-density lipoprotein; HOMA-IR, homeostasis model insulin resistance index; ISI, insulin sensitivity index; DN, diabetic nephropathy; PEG-b-(PELG₅₀-g-PLL₃), poly(ethylene glycol)-b-brush poly(L-lysine) polymer.