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. 2017 Jul 6;7:4770. doi: 10.1038/s41598-017-05047-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Retinoic Acid affects the growth of TKI resistant NSCLC cells. (a) Cell viability assay (MTT) of A549, HCC827 and H-1975 NSCLC cell lines treated with 1 and 10 µM RA for 24–48 and 72 hrs. Black arrows indicate the effect of RA on the TKI resistant H-1975 NSCLC cell line (right and left panel). Data are represented as mean ± SD and indicate the percentage of RA treated cells versus an untreated control (n = 4). (b) Representative Annexin V/PI assay analyzed by FACS to assess whether RA treatment induces apoptosis in H-1975 cells (n = 3). (c) Cell cycle analysis of H-1975 NSCLC cells treated with 1 and 10 µM RA for 72 hours (n = 4). Statistical analysis has been obtained by unpaired multiple t test.