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. 2017 Jul 6;7:4767. doi: 10.1038/s41598-017-04965-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time-dependent uptake of L-homoarginine in HEK cells overexpressing CAT1 (a), CAT2A (b) or CAT2B (c). Cells were incubated for 1, 2.5, 5, 10, and 30 min at 37 °C with 100 μM L-homoarginine. Each data point is n = 6. ***p < 0.001 as compared to suitable cells (HEK VC_G418 or HEK VC_Hygro) containing only an empty vector.