Table 2.
Established Arrhythmogenic CardioMyopathy (ACM) major or minor diagnostic criteria7 and clinical characteristics in Idiopathic Ventricular Tachycardia (IVT) vs. ACM patients.
| IVT | ACM | p IVT vs. ACM | ||
|---|---|---|---|---|
| Global or regional dysfunction and structural alteration n (%) | Minor | 2 (9.52) | 12 (33.33) | 0.04 |
| Major | 0 (0) | 18 (50) | <0.01 | |
| Tissue characterization n (%) | Minor | — | 2 (8.69) | — |
| Major | — | 12 (52.17) | — | |
| Repolarization abnormalities n (%) | Minor | 4 (0.19) | 9 (0.25) | 0.61 |
| Major | 1 (0.05) | 17 (0.47) | <0.01 | |
| Depolarization abnormalities n (%) | Minor | 0 (0) | 8 (22.22) | 0.02 |
| Major | 0 (0) | 10 (27.78) | <0.01 | |
| Arrhythmias n (%) | Minor | 21 (100) | 15 (41.67) | <0.01 |
| Major | 0 (0) | 17 (47.22) | <0.01 | |
| Family history n (%) | Minor | 0 (0) | 4 (11.11) | 0.11 |
| Major | 0 (0) | 8 (22.22) | 0.02 | |
| LVEF (%) | 58.85 ± 1.29 | 58.55 ± 1.75 | 0.91 | |
| TAPSE (mm) | 24.72 ± 0.93 | 19.94 ± 0.83 | <0.01 | |
| MAE n (%) | 2 (9.52) | 24 (66.67) | <0.01 | |
| BNP (pg/ml) | 21.88 ± 3.11 | 46.85 ± 8.34 | 0.15 | |
| miR-320a (relative expression) | 1 ± 0.10 | 0.78 ± 0.05 | 0.03 | |
LVEF, Left Ventricular Ejection Fraction (n = 21 IVT, n = 35 ACM); TAPSE, Tricuspid Annular Plane Systolic Excursion (n = 18 IVT, n = 35 ACM); MAE, Prior Major Arrhythmic Events (n = 21 IVT, n = 36 ACM); BNP, Brain Natriuretic Peptide (n = 20 IVT, n = 32 ACM).