Table 2.

Regions of increased Pittsburgh compound B retention in the EOAD and LOAD groups compared with the normal control group, and in the EOAD group compared with the LOAD group (P<0.05, FDR; extent threshold =50 voxels; local maximum more than 8.0 mm apart)

Coordinates x, y, z			Anatomic location	z score	Cluster size
EOAD>NC
−52	−44	16	Lt. Sup. temporal gyrus, WM	5.74	39,105
0	4	48	Lt. Sup. frontal gyrus	5.13
−54	−50	−12	Lt. Inf. temporal gyrus, WM	5.03
2	−52	62	Rt. parietal lobe, precuneus	4.50	1,340
22	−52	64		3.60
−10	−74	44	Lt. parietal lobe, precuneus, WM	3.37
26	−38	−18	Rt. cerebellum, Ant. lobe	3.42	267
−28	−36	−20	Lt. cerebellum, Ant. lobe	3.31	127
−32	2	62	Lt. Mid. frontal gyrus	3.26	222
−24	−4	68		3.00
LOAD>NC
−6	−16	48	Lt. medial frontal gyrus, WM	4.58	14,735
0	4	48	Lt. Sup. frontal gyrus	4.54
2	−58	26	Rt. cingulate gyrus	4.52
−54	38	4	Lt. Inf. frontal gyrus	4.53	1,260
−58	20	12	Lt. Inf. frontal gyrus	3.02
−28	50	22	Lt. Sup. frontal gyrus	2.50
0	−50	64	Interhemispheric	4.09	1,446
28	−54	60	Rt. Sup. parietal lobule	3.79
−10	−74	44	Lt. precuneus, WM	3.35
−54	−58	−18	Lt. cerebellum, Post. lobe	4.03	2,999
−56	−52	18	Lt. Sup. temporal gyrus, WM	3.95
−66	−42	−2	Lt. Mid. temporal gyrus	3.52
60	−44	−4	Rt. Mid. temporal gyrus, WM	3.77	1,983
58	−42	28	Rt. Inf. parietal lobule	2.89
52	−66	2	Rt. Inf. temporal gyrus	2.83
−24	10	−2	Lt. lentiform nucleus	2.94	77
20	10	−4	Rt. lentiform nucleus	2.93	71
EOAD>LOAD
−8	−10	6	Lt. thalamus	4.61	2,084
20	0	4	Rt. lentiform nucleus	4.40
−18	−4	14	Lt. extranuclear, WM	4.34
−32	−48	−10	Lt. fusiform gyrus, WM	3.59	119
−26	−54	8	Lt. extranuclear, WM	3.40

Abbreviations: EOAD, early-onset Alzheimer’s disease; LOAD, late-onset Alzheimer’s disease; FDR, false discovery rate; NC, normal control; Lt., left; Sup., superior; WM, white matter; Inf., inferior; Rt., right; Ant., anterior; Mid., middle; Post., posterior.