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. 2017 Jul 6;7:4772. doi: 10.1038/s41598-017-05118-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The Additivity Index reveals that the persistence of the multisensory integration deficit induced by noise-rearing is reversed by cross-modal (VA) training. This index uses the sum of the comparator unisensory responses as a benchmark with which to evaluate multisensory integration. Note the difference between the normal scatter plot (A) (each point represents a single neuron) and those after noise-rearing (B), and after 6 and 12 months of housing in a normal environment (C,D). Only after cross-modal training does the scatter plot approximate that seen in the normal animal (E).