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. 2017 Jul 6;7:4772. doi: 10.1038/s41598-017-05118-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Population data showing the time course of receptive field register and multisensory integration capabilities over the cross-modal exposure sessions relative to controls. (A) While the t-score representing visual-auditory RF register remained high (misalignment) in noise-reared animals subsequently housed in the normal environment for 12 months (NE-12), the t score in animals in the cross-modal trained group gradually decreased. (B) Similarly, while there was no significant increase in either the incidence of neurons showing multisensory integration capabilities (filled circles) or their enhancement index in the NE-12 animals, these scores gradually increased to reach adult-like levels for neurons in the VA trained group. (C) Improvements in RF register and ME were highly correlated on a sample-by-sample basis: neurons with greater levels of RF register more likely to show higher levels of multisensory enhancement (r = −0.8).