Table 5.
CFR for dicloxacillin at different dosage regimens
| Dosage regimens | Haemophilus influenzae (n=54) | Moraxella catarrhalis (n=56) | MSSA (n=388) | CNS (n=53) | Streptococcus pneumoniae (n=262) | Other Streptococcus isolates (n=54) | Gram-positive bacteria (n=757) | Total (n=867) |
|---|---|---|---|---|---|---|---|---|
| 250 mg qd | 0.0% | 1.8% | 89.6% | 71.8% | 3.6% | 31.0% | 54.4% | 47.6% |
| 500 mg qd | 0.2% | 1.8% | 96.2% | 73.7% | 7.7% | 38.9% | 59.9% | 52.4% |
| 1,000 mg qd | 1.4% | 1.8% | 97.9% | 80.2% | 13.1% | 57.2% | 64.4% | 56.4% |
| 2,000 mg qd | 4.9% | 1.8% | 98.4% | 89.9% | 20.6% | 84.7% | 69.9% | 61.5% |
| 250 mg q6h | 25.1% | 1.8% | 98.7% | 94.3% | 30.6% | 90.7% | 74.2% | 66.5% |
| 500 mg q6h | 37.3% | 1.8% | 98.9% | 94.3% | 51.8% | 95.8% | 82.0% | 74.1% |
Abbreviations: CFR, cumulative fraction of response; CNS, coagulase-negative Staphylococcus; MSSA, methicillin-sensitive Staphylococcus aureus; qd, once-daily; q6h, every 6 hours.