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. 2017 Jul 6;7:4757. doi: 10.1038/s41598-017-04784-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Localization of functionalized nanoparticles in a cellular context with correlative microscopy. (a) Part of a HeLa cell containing functionalized nanoparticles was first identified using fluorescent microscopy. (b) The same region was imaged using a coarse STXM scan. (c) A fine STXM scan was then performed on a smaller region of interest and a tomographic tilt series was acquired from this region. (d) Ptychographic imaging was performed on the same region as (c) to obtain higher resolution information. (e) Individual nanoparticles within and around the leading edge of the cell identified from the ptychographic reconstruction.