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. 2017 Jul 6;7:4835. doi: 10.1038/s41598-017-04838-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Alteration of osmotic gradient modulates renal Δ6 MR expression in vivo. RT-qPCR analysis of MR expression (FL MR and Δ6 MR) in the kidneys of mice subjected to furosemide treatment, a high Na⁺ diet, water deprivation or water intoxication. The FL MR and Δ6 MR transcripts were reverse-transcribed, amplified specifically with appropriate primers and quantified with Taqman probes. Levels of mRNA for the FL MR or Δ6 MR were normalized relative to 18s rRNA and expressed as a fold-induction relative to the level of expression in the kidneys of control animals, arbitrarily set at 1. The data shown are means ± SEM (n = 10–24) of two independent experiments. The Δ6/FL MR ratio was also determined for each set of conditions. **P < 0.01; ***P < 0.001; NS = not significant (Mann-Whitney U-tests).