Figure 3.

The blood glucose dynamics during the experiment. Blood glucose levels measured under fasting conditions every week from the beginning of the experiment are shown as M ± SEM. Black circles—intact group of healthy animals, receiving saline (5 ml/kg per os); red rectangles—control group with streptozotocin–nicotinamide diabetes (StD), receiving saline (5 ml/kg per os); and orange triangles—experimental group with StD, receiving the novel GPR119 agonist ZB-16 (1 mg/kg, dissolved in 5 ml/kg of saline, per os). All procedures were performed once a day at the morning. Repeated measures two-way ANOVA: time—p = 0.029; treatment—p < 0.0001; time × treatment—p = 0.401. Newman–Keuls post hoc test: for intact group p < 0.001 both with control and ZB-16 groups from 0th to 21st day of experiment; 28th day: *p < 0.05, **p < 0.01, and ***p < 0.001 (comprised data sets are shown with vertical lines).