Figure 8.

The morphometric changes in pancreatic islets. The figure shows the morphometric assay results performed after 28 days of treatment. Top: left—islet area, μm²; right—islet perimeter, μm²; bottom: left—area of insulin-positive endocrine cells, μm²; right—relative area of insulin-positive endocrine cells, %. All data shown as M ± SEM. Black—intact group of healthy animals, receiving saline (5 ml/kg per os); red—control group with streptozotocin–nicotinamide diabetes (StD), receiving saline (5 ml/kg per os); orange—experimental group with StD, receiving the novel GPR119 agonist ZB-16 (1 mg/kg, dissolved in 5 ml/kg of saline, per os). One-way ANOVA, Newman–Keuls post hoc test: *p < 0.01, **p < 0.01, and ***p < 0.001 (comprised data sets are shown with horizontal lines).