FIGURE 2.

Gliotoxin efficiently targets melanoma tumors in athymic nude mice. A single day dosing schedule (5-0-2.5 mg/kg) of gliotoxin was intraperitoneally applied to 518A2 xenotransplanted mice (A) on day 11 (group A, early stage tumor model) and (B) on day 25 (group B, late stage tumor model) as indicated. The effect of gliotoxin on the tumor volume in the treatment groups (indicated as white circles) relative to the control group (indicated as black squares) was determined by serial caliper measurements. Data is given as mean ± 95% confidence interval. Δ values indicate the maximum percentage of tumor mass reduction relative to controls mediated by gliotoxin in these two groups. ^∗Denotes the beginning of statistical significance.