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. 2017 Jul 7;8:450. doi: 10.3389/fphar.2017.00450

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Copyright © 2017 Barker, Bryant, Osborne and Chandler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Acquisition of sucrose seeking in rats exposed to ethanol. (A) In adult male rats that had been subject to adolescent intermittent ethanol (AIE), responding on the RR lever was significantly higher than responding on the RI lever on days 2 and 12 (arrows). In control (AIR) male rats, responding was significantly higher on the RR lever on days 3, and 10–13. (B) In adult female rats that had been subject to AIE, no differences in response rates were observed between AIE and AIR exposed rats. Responding was significantly higher on the RR lever than the RI lever on the final 3 days or RI60/RR10 responding for both groups. (C) In male rats subjected to intermittent ethanol (ETOH) exposure in adulthood, no differences in responding between ethanol-exposed and control rats were observed, nor did adult ethanol exposure alter response rates on the RR and RI levers. (D) In female rats exposed to ethanol in adulthood, no significant differences in responding on RR versus RI levers were observed. ↓p < 0.05; ^∗p < 0.05.