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Ser320 on RIPK1 is dispensable for canonical NFκB signaling. A, Representative immuno-blots comparing canonical NFκB signaling in Jurkat RIPK1−/− cells reconstituted with wild-type RIPK1, RIPK1-S166A, or RIPK1-S320A. The cell lines were exposed to TNFα for the indicated times, the cells lysed, and immuno-blotted with the indicated antibodies. B, Proposed model for the significance of RIPK1 phosphorylation at Ser320 in response to TNFα. See text for details.
