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Binding affinity predictions by Model 1 for Wnt-Fzd interactions. A, mouse interactions. B, human interactions. C, binding affinity differences (ΔKd) between equivalent Wnt-Fzd interactions of mouse and human calculated as ΔKd = mouse Kd − human Kd. Positive ΔKd is indicative of a lower affinity interaction in mouse compared with human; negative ΔKd indicates a higher affinity interaction in mouse compared with human.
