Figure 1.

Ablation of Mgp, but not Bglap, causes craniofacial malformations. A, lateral cephalic photographs of WT, Mgp^−/−, and Bglap^−/− mice showing a blunt and shorter snout in Mgp^−/− mice. B, frontal cephalic photographs confirming the abnormal craniofacial phenotype in Mgp^−/− mice. C, superimposition of the lateral and frontal cephalic photographs showing a comparable facial profile between WT and Bglap^−/− mice and a blunt and wider profile in Mgp^−/− mice. D, lateral cephalic X-ray of WT, Mgp^−/−, and Bglap^−/− mice. Mgp^−/− mice show a severe anterior cross-bite with a radiopaque nasal structure (asterisk and arrow, respectively). E, 3D reconstruction of micro-CT scans of WT and Mgp^−/− mice confirming the dental malocclusion and craniofacial deformities in the latter genotype.