Figure 3.

The Ctr1 and Ctr2 genes contain similar promoter elements. A, DNA regions 1 kb upstream of the transcription start site, located at the 5′ region of the 5′ UTR, for Ctr1 and Ctr2 were identified via the UCSC Genome Browser, and ChIP-seq data from the ENCODE Consortium were analyzed. Proteins that bound to both promoters are displayed in the center of the Venn diagram, whereas those found to occupy only one of the two promoters are shown in the non-overlapping portion of the diagram. B, Ctr1 and Ctr2 promoters from the indicated 10 species were analyzed with the ConTra v2 server under standard parameters for predicted transcription factor binding sites. Transcription factors are displayed as colored blocks placed above their binding location. A black rectangle indicates the predicted presence of a transcription factor-binding site in the indicated species.