Figure 4.

Ctr2 genomic loci are similar to Ctr1 but lack an exon coding for the copper-binding ecto-domain. A, genomic data for Ctr1 and Ctr2 from the listed species were downloaded from Ensembl and aligned to compare intron/exon structure. Exons are represented by green (Ctr1) and orange (Ctr2) rectangles, whereas introns are displayed as black lines. Purple rectangles represent UTRs. B, depiction of the general architecture of Ctr genes with regions encoding the metal binding ecto-domain, the intracellular loop, three transmembrane domains, and the cytosolic tail. Ctr1 and Ctr2 share a similar intron/exon structure, with the notable exception that Ctr2 lacks the exon coding for a large ecto-domain. The dashed red line indicates the region of difference.