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. 2017 Jul;187(7):1523–1536. doi: 10.1016/j.ajpath.2017.02.019

Figure 6.

Figure 6

Transient siRNA knockdown of RUNX1 suppresses invasion and vimentin and L-plastin mRNA expression. A: Quantitative real-time RT-PCR (RT-qPCR) analysis of the mRNA abundance of RUNX1 in UM-SCC-1 siRNA transfectants. B: Representative Western blots of RUNX1 with β-actin as loading control and its quantification. C: Epidermal growth factor–stimulated invasion of cells treated with nontargeting (siNT) and RUNX1 (siRUNX1) siRNA. D: Quantitative real-time RT-PCR (RT-qPCR) analysis of the mRNA expression of L-plastin and vimentin. ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001.