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. 2017 Jul 3;8:16042. doi: 10.1038/ncomms16042

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) The neocortex is built in an inside-out manner in which neurons born from deeply located germinal zone migrate past earlier-born neurons to reside in more superficial layers. Note that initially, the preplate (PP) is split into a subplate (SP) and superficially located marginal zone (MZ) by incoming L6 neurons, such that early born neurons are later found in L1. Direct neurogenesis from the ventricular zone (VZ) predominates at early developmental stages, while indirect neurogenesis from the subventricular zone (SVZ) progressively increases during corticogenesis. E: Embryonic day; MZ: marginal zone; PP: preplate; SP: subplate. (b) FlashTag (FT) labelling highlights neurons born in the VZ through direct neurogenesis (ref. ⁵⁵).