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. 2017 Jul 4;8:15952. doi: 10.1038/ncomms15952

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The pathway includes the three processing enzymes Lgt, LspA and Lnt that reside in the inner membrane. Pre-prolipoproteins enter the membrane for processing via the Sec or TAT pathways. Trafficking to the outer membrane is by way of the Lol ABC transporter system. The inset shows the chemical structure of the triacylated N-terminal cysteine of a mature lipoprotein. DAG, diacylglyceryl.