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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Am Soc Mass Spectrom. 2016 Sep 19;28(1):190–199. doi: 10.1007/s13361-016-1500-3

Figure 1. The effect of different fluorinated alcohols on MS signal intensity of a 33-mer phosphorothioate in the presence of four different alkylamine IP agents.

Figure 1

It can be observed that in the absence of IP agents, the addition of these alcohols does not have a significant effect on electrospray MS signal intensity. The only exception is NFTB that causes considerable MS signal suppression. It was exactly because of this suppression effect that NFTB was only used to a final concentration of 2 mM while other alcohols were used at a concentration of 25 mM. It is also clear that in the case of DMCHA and OA, other fluorinated alcohols (with the exception of NFTB) show a better performance than HFIP.