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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Am Soc Mass Spectrom. 2016 Sep 19;28(1):190–199. doi: 10.1007/s13361-016-1500-3

Figure 3. The effect of NFTB on stabilizing secondary oligonucleotide structures.

Figure 3

Top panels show the mass spectra of phosphorothioate infused in a solution of OA/HFIP (a) or OA/NFTB (b). Bottom panels show the mass spectra of the ssDNA strand in a solution of OA/HFIP (c) or OA/NFTB (d). Oligonucleotides sprayed from OA/NFTB solutions adopt a secondary structure with a lower charge state regardless of their type.