Table 3.
Optimized mobile phase conditions for the LC-MS analysis of various oligonucleotides
| Oligonucleotide type | Optimum IP agent | Optimal fluorinated alcohol |
|---|---|---|
| ssDNA | TEA | HFIP |
| RNA | DBA | HFMIP |
| Phosphorothioate | DMCHA | HFMIP |
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