Table 2.
Baseline imaging and cardiopulmonary exercise testing results, divided by median baseline IGFBP7 concentration.
| Spearman correlation | ||||||
|---|---|---|---|---|---|---|
| Characteristic | N | IGFBP7 < 219ng/mL | IGFBP7 > 219 ng/mL | Wilcoxon with rank sum baseline P value | IGFBP7 (ρ) | Spearman correlation P value |
| Baseline echocardiography | ||||||
| MV inflow: E velocity at leaf tip (m/sec), median (IQR) | 151 | 0.9 (0.7, 1.1) | 1.1 (0.9, 1.4) | <0.0001 | 0.395 | <0.0001 |
| MV inflow: A velocity at leaf tip (m/sec), median (IQR) | 112 | 0.7 (0.5, 0.9) | 0.6 (0.4, 0.9) | 0.30 | −0.066 | 0.49 |
| E/A ratio, median (IQR) | 112 | 1.18 (1.00, 1.80) | 1.80 (1.13, 3.25) | 0.01 | 0.258 | 0.006 |
| LV relaxation septal - E' (m/sec), median (IQR) | 146 | 0.06 (0.05, 0.08) | 0.06 (0.04, 0.07) | 0.047 | −0.203 | 0.01 |
| Filling pressure septal (medial) - E/E' (m/sec), median (IQR) | 143 | 13.3 (10.0, 18.2) | 18.3 (13.3, 26.7) | <0.001 | 0.398 | <0.0001 |
| LA volume index (mL/m2), median (IQR) | 113 | 40.3 (31.7, 47.3) | 53.9 (39.8, 63.1) | <0.001 | 0.386 | <0.0001 |
| RVSP (mmHg), median (IQR) | 103 | 35.7 (32.0, 43.6) | 48.4 (36.4, 56.0) | <0.001 | 0.413 | <0.0001 |
| LV mass index (g/m2), median (IQR) | 117 | 65.6 (56.5, 83.3) | 80 (67, 103) | 0.006 | 0.227 | 0.01 |
| LV hypertrophy, N (%) | 117 | 22 (37.9) | 35 (59.3) | 0.021 | 0.234 | 0.01 |
| LV end diastolic volume index (mL/m2), median (IQR) | 79 | 48.8 (42.8, 55.0) | 55.8 (45.0, 65.2) | 0.09 | 0.189 | 0.10 |
| LV end systolic volume index (mL/m2), median (IQR) | 79 | 18.4 (15.9, 22.5) | 23.0 (16.4, 30.7) | 0.13 | 0.158 | 0.16 |
| LVEF (%),median (IQR) | 159 | 60.5 (57.5, 68.0) | 60 (55, 65) | 0.24 | −0.134 | 0.09 |
| Baseline cardiac MRI | ||||||
| LV stroke volume (mL), median (IQR) | 88 | 67.2 (60.3, 82.3) | 81.2 (69.2, 94.1) | 0.05 | 0.121 | 0.27 |
| LV mass index (g/m2), median (IQR) | 88 | 59.7 (49.3, 73.0) | 63.8 (54.1, 85.5) | 0.10 | 0.218 | 0.04 |
| LV end diastolic volume index (mL/m2), median (IQR) | 88 | 50.4 (43.1, 58.4) | 60.6 (53.9, 69.3) | 0.004 | 0.225 | 0.04 |
| LV end systolic volume index (mL/m2), median (IQR) | 88 | 17.3 (14.0, 22.1) | 22.3 (18.8, 27.3) | 0.02 | 0.186 | 0.08 |
| LVEF (%), median (IQR) | 88 | 67.2 (59.6, 72.1) | 63.7 (57.3, 68.3) | 0.20 | −0.101 | 0.35 |
| Cardiac index (L/min/m2), median (IQR) | 87 | 2.23 (1.82, 2.52) | 2.4 (2.01, 2.77) | 0.17 | 0.106 | 0.33 |
| Aortic distensibility (10−3 mmHg−1), median (IQR) | 61 | 1.22 (0.74, 2.05) | 0.79 (0.55, 1.70) | 0.08 | −0.301 | 0.02 |
|
| ||||||
| CPET | ||||||
| Baseline peak VO2 (ml/min/kg), median (IQR) | 160 | 13.2 (11.1, 16.1) | 11.1 (9.9, 13.4) | <0.0001 | −0.339 | <0.0001 |
MV= mitral valve, IQR= interquartile range, LV= left ventricle, LA= left atrium, RVSP= estimated right ventricular systolic pressure, LVEF= left ventricular ejection fraction, MRI= magnetic resonance imaging, CPET= cardiopulmonary exercise testing, VO2max= peak oxygen consumption