Table 4.

Change in IGFBP7 and imaging parameters over 24 weeks.

Diastolic function measure	N	Spearman correlation with change in IGFBP7 (ρ)	Spearman correlation P value	Adjusted P value
Echocardiography change from baseline to week 24
MV inflow: E velocity at leaf tip (m/sec)	144	0.114	0.17	0.006
MV inflow: A velocity at leaf tip (m/sec)	102	−0.141	0.16	0.14
E/A ratio	102	0.225	0.02	0.02
LV relaxation septal (medial) - E' (m/sec)	135	−0.096	0.27	0.06
Filling pressure septal (medial) - E/E' (m/sec)	133	0.174	0.05	0.001
LA volume index	99	0.024	0.81	0.52
RVSP (mmHg)	88	0.282	0.008	0.03
Cardiac MRI change from baseline to week 24
LV stroke volume	78	−0.674	0.56	0.75
Cardiac index	77	−0.139	0.23	0.25
Aortic distensibility	46	0.067	0.66	0.90

MV= mitral valve, LV= left ventricle, LA= left atrium, RVSP= estimated right ventricular systolic pressure, MRI= magnetic resonance imaging, CPET= cardiopulmonary exercise testing, VO_2max= peak oxygen consumption