Table 3.
Adjusted cox models of CRC risk stratified by sex
| Variable | Females | Males | ||||
|---|---|---|---|---|---|---|
| Univariate HR (95% CI) | Multivariate HR (95% CI) | Multivariate HR (95% CI) with interaction |
Univariate HR (95% CI) | Multivariate HR (95% CI) | Multivariate HR (95% CI) with interaction |
|
| Overall | ||||||
| Immigrant | 0.63 (0.60, 0.66) | 0.64 (0.61, 0.67) | 0.59 (0.56, 0.62) | 0.59 (0.56, 0.62) | ||
| Nonimmigrant controls | Reference | Reference | Reference | Reference | ||
| Age at index | ||||||
| 40 - 49 | Reference | Reference | Reference | Reference | Reference | Reference |
| 50 - 59 | 2.35 (2.25, 2.45) | 2.35 (2.25, 2.45) | 2.35 (2.25, 2.45) | 2.59 (2.50, 2.70) | 2.60 (2.50, 2.70) | 2.60 (2.50, 2.70) |
| 60 - 69 | 4.54 (4.36, 4.73) | 4.53 (4.35, 4.72) | 4.53 (4.35, 4.72) | 4.94 (4.77, 5.12) | 4.94 (4.77, 5.12) | 4.94 (4.77, 5.12) |
| 70 - 74 | 6.54 (6.19, 6.91) | 6.52 (6.17, 6.88) | 6.52 (6.17, 6.88) | 6.99 (6.62, 7.37) | 6.98 (6.62, 7.37) | 6.98 (6.62, 7.37) |
| > = 75 | 8.63 (8.11, 9.17) | 8.63 (8.12, 9,17) | 8.63 (8.12, 9.17) | 8.46 (7.93, 9.03) | 8.47 (7.94, 9.04) | 8.47 (7.94, 9.04) |
| Immigrant < = 10 years since index date | 0.62 (0.58, 0.66) | 0.63 (0.59, 0.67) | 0.55 (0.52, 0.59) | 0.55 (0.52, 0.59) | ||
| Controls <= 10 years since index date | Reference | Reference | Reference | Reference | ||
| Immigrant > 10 years since index date | 0.65 (0.58, 0.73) | 0.66 (0.59, 0.74) | 0.64 (0.57, 0.72) | 0.63 (0.57, 0.71) | ||
| Controls <= 10 years since index date | Reference | Reference | Reference | Reference | ||
| Age adjusted models for world region of birth | ||||||
| East Asia and Pacific | ||||||
| Immigrant < = 10 years since index date | 0.70 (0.63, 0.78) | 0.72 (0.65, 0.80) | 0.70 (0.64, 0.78) | 0.72 (0.65, 0.79) | ||
| Controls <= 10 years since index date | Reference | Reference | Reference | Reference | ||
| Immigrant > 10 years since index date | 0.79 (0.66, 0.95) | 0.80 (0.67, 0.96) | 0.74 (0.62, 0.89) | 0.73 (0.61, 0.87) | ||
| Controls <= 10 years since index date | Reference | Reference | Reference | Reference | ||
| Europe and Central Asia | ||||||
| Immigrant< = 10 years since index date | 1.10 (0.98, 1.23) | 1.09 (0.97, 1.22) | 1.02 (0.90, 1.15) | 1.01 (0.90, 1.14) | ||
| Controls <= 10 years since index date | Reference | Reference | Reference | Reference | ||
| Immigrant > 10 years since index date | 0.96 (0.77, 1.18) | 0.96 (0.78, 1.19) | 1.05 (0.85, 1.30) | 1.04 (0.84, 1.29) | ||
| Controls <= 10 years since index date | Reference | Reference | Reference | Reference | ||
| Latin America and the Caribbean | ||||||
| Immigrant < = 10 years since index date | 0.58 (0.47, 0.71) | 0.59 (0.48, 0.72) | 0.45 (0.35, 0.57) | 0.46 (0.36, 0.58) | ||
| Controls <= 10 years since index date | Reference | Reference | Reference | Reference | ||
| Immigrant > 10 years since index date | 0.56 (0.39, 0.81) | 0.58 (0.41, 0.84) | 0.46 (0.30, 0.71) | 0.46 (0.30, 0.71) | ||
| Controls <= 10 years since index date | Reference | Reference | Reference | Reference | ||
| Middle East and North Africa | ||||||
| Immigrant< = 10 years since index date | 0.52 (0.40, 0.67) | 0.52 (0.40, 0.68) | 0.49 (0.39, 0.61) | 0.48 (0.38, 0.60) | ||
| Controls <= 10 years since index date | Reference | Reference | Reference | Reference | ||
| Immigrant > 10 years since index date | 0.54 (0.33, 0.87) | 0.54 (0.34, 0.88) | 0.72 (0.49, 1.07) | 0.70 (0.47, 1.03) | ||
| Controls <= 10 years since index date | Reference | Reference | Reference | Reference | ||
| South Asia | ||||||
| Immigrant < = 10 years since index date | 0.23 (0.19, 0.28) | 0.24 (0.19, 0.29) | 0.17 (0.14, 0.21) | 0.18 (0.14, 0.22) | ||
| Controls <= 10 years since index date | Reference | Reference | Reference | Reference | ||
| Immigrant > 10 years since index date | 0.24 (0.17, 0.35) | 0.25 (0.17, 0.37) | 0.28 (0.20, 0.40) | 0.28 (0.20, 0.40) | ||
| Controls <= 10 years since index date | Reference | Reference | Reference | Reference | ||
| Sub-saharan Africa | ||||||
| Immigrant < = 10 years since index date | 0.27 (0.17, 0.43) | 0.27 (0.17, 0.43) | 0.39 (0.26, 0.59) | 0.38 (0.25, 0.57) | ||
| Controls <= 10 years since index date | Reference | Reference | Reference | Reference | ||
| Immigrant > 10 years since index date | 0.56 (0.26, 1.18) | 0.56 (0.26, 1.18) | 0.78 (0.40, 1.53) | 0.75 (0.38, 1.48) | ||
| Controls <= 10 years since index date | Reference | Reference | Reference | Reference | ||