Table 3.

Cross-sectional association between plasma PAI-1 and age-adjusted LTL among SHFS participants

PAI-1 level	Unadjusted		Model 1*		Model 2†
	β (SE)	P	β (SE)	P	β (SE)	P
Continuous
Log-PAI-1	−0.023 (0.006)	<0.001	−0.015 (0.007)	0.029	−0.015 (0.007)	0.032
Quartiles
Quartile 1	reference	–	reference	–	reference	–
Quartile 2	−0.011 (0.011)	0.300	−0.015 (0.011)	0.160	−0.016 (0.011)	0.145
Quartile 3	−0.023 (0.010)	0.020	−0.024 (0.011)	0.033	−0.025 (0.011)	0.027
Quartile 4	−0.041 (0.011)	<0.001	−0.027 (0.013)	0.040	−0.028 (0.013)	0.035
P for trend		<0.001		0.035		0.030

LTL: leukocyte telomere length; PAI-1: plasminogen activator inhibitor-1; Log-PAI-1: log-transformed plasminogen activator inhibitor-1.

^*Model 1 adjusted for demographics (sex, education level), study site, lifestyle factors (current smoking, current drinking, physical activity), and metabolic factors (waist circumference, systolic blood pressure, fasting glucose, insulin, low- and high- density lipoprotein cholesterol, estimated glomerular filtration rate).

^†Model 2 adjusted for covariates in model 1 plus log-transformed high sensitivity C-reactive protein.