Table 1.

Known long-lived proteins.

Tissue	Long-lived proteins
Lens	Crystallins[12] Aquaporin 0 [62]
Vitreous	Collagen[63]
Retina	Histones[64] Lamins B1 & B2[65]
Brain	Myelin basic protein[17] Myelin proteolipid protein [59] Myelin oligodendrocyte glycoprotein[17] 2′,3′-Cyclic-nucleotide 3′-phosphodiesterase[17] Histones [17] Tau[17] Aβ peptide[49] Isoaspartyl peptidase/L-asparaginase[49] NAD-dependent protein deacetylase sirtuin-2[17] Nucleoporins[17] Lamins B1 & B2[17] Neurofilament medium polypeptide [17] Ectonucleotide pyrophosphatase/phosphodiesterase[17] Immunoglobulin superfamily member 8[17] Tubulin[66] Proteoglycans[67] SOD1[20] Versican core protein[17] Immunoglobulin superfamily member 8[17] Collagen[17]
Motor Neuron	TPD43[68]
Heart, Arteries	Elastin[3] Collagen[69] Histone H4[70] Lamin B1[70]
Lung	Elastin[5] Collagen[69]
Teeth	Dentine phosphoprotein [71]
Liver	Serine hydroxymethyltransferase[72]
Muscle	Collagen [6] PKA catalytic subunit[73] Myosin[74]
Blood (Erythrocytes)	Membrane protein band 4.1 [75] Ankyrin[76]
Skin	Elastin[8] Collagen[69]
Hair	Keratin
Bone	Collagen[2, 69] Osteocalcin[7]
Epiglottis	Elastin[15]
Cartilage	Proteoglycans[78] Collagen[42]
Oocytes	Rec8[16] Serine hydroxymethyltransferase[9]
Fat Cells	Unknown proteins[11]
Tendons	Collagen[69]
Ligaments	Collagen[69]