Fig. 3.

SNV patterns. a Relative contribution of the six SNV classes. b Heatmap is based on the log-transformed percentage of each SNV type with each SNV context corrected for the frequency of the trinucleotide in the reference genome. c + d SNV density plots for MSI tumor (c) and MSS tumor (d). Rainfall plots are based on all somatic SNVs. The x-axis shows the mutations ordered by position. The distance between each mutation and the prior variant is plotted on the y-axis. The colors of the dots indicate the SNV-types